Airflow Obstruction in Never Smokers in Five Latin American Cities: The聽PLATINO Study

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• 作者：Rogelio Perez-Padilla^a ; ^g ; ^{perezpad@servidor.unam.mx} ; Rosario Fernandez^a ; ^g ; Maria Victorina Lopez Varela^b ; ^g ; Maria Montes de Oca^c ; ^g ; Adriana Muiñ ; o^b ; ^g ; Carlos Tá ; lamo^c ; ^g ; José ; Roberto Brito Jardim^d ; ^g ; Gonzalo Valdivia^e ; ^g ; Ana Maria Baptista Menezes^f ; ^g
• 关键词：Chronic pulmonary disease ; Epidemiology ; Never smokers ; Health status ; Tobacco smoking
• 刊名：Archives of Medical Research
• 出版年：2012
• 期刊代码：24_01884409
• 类别：med
• 出版时间：February, 2012
• 卷：43
• 期：2
• 页码：159-165
• 文件大小：223 K

摘要

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Background

Although chronic obstructive pulmonary disease (COPD) is mostly related to tobacco smoking, a variable proportion of COPD occurs in never smokers. We investigated differences between COPD in never smokers compared with smokers and subjects without COPD.

Methods

PLATINO is a cross-sectional population-based study of five Latin American cities. COPD was defined as postbronchodilator FEV₁/FVC <0.70 and FEV₁ <80%of predicted values.

Results

Among 5,315 subjects studied, 2278 were never smokers and 3036 were ever smokers. COPD was observed in 3.5%of never smokers and in 7.5%of ever smokers. Never smokers with COPD were most likely older and reported a medical diagnosis of asthma or previous tuberculosis. Underdiagnosis was as common in obstructed patients who never smoked as in ever smokers.

Conclusions

Never smokers comprised 26%of all individuals with airflow obstruction. Obstruction was associated with female gender, older age and a diagnosis of asthma or tuberculosis.