Enantioselective epoxidation of chalcones and naphthoquinones mediated by (+)-norcamphor-derived hydroperoxide

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• 作者：Lattanzi ; Alessandra ; Cocilova ; Maria ; Iannece ; Patrizia ; Scettri ; Arrigo
• 刊名：Tetrahedron ; Asymmetry
• 出版年：2004
• 期刊代码：108_09574166
• 类别：ch
• 出版时间：November 29, 2004
• 卷：15
• 期：23
• 页码：3751-3755
• 文件大小：285 K

摘要

(+)-Norcamphor-derived hydroperoxide has been employed in the asymmetric epoxidation of electron poor alkenes such as trans-chalcones and naphthoquinones. Optimization of the reaction conditions required the employment of n-BuLi/THF at 芒芒芒20芒芒C to achieve ees up to 58%. The epoxide of vitamin K₃ has now been obtained with the best up to now reported value of enantioselectivity (51%ee).