The high producer variant of the Fc-receptor like-3 (FCRL3) gene is involved in protection against multiple sclerosis

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• 作者：Fuencisla Matesanz ; Oscar Fern&#xe1 ; ndez ; Roger L. Milne ; Maria Fedetz ; Laura Leyva ; Miguel Guerrero ; Concepció ; n Delgado ; Miguel Lucas ; Guillermo Izquierdo ; Antonio Alcina
• 关键词：Multiple sclerosis ; FCRL3 ; SNP ; Polymorphisms ; Genetic factor
• 刊名：Journal of Neuroimmunology
• 出版年：2008
• 期刊代码：32_01655728
• 类别：neu
• 出版时间：March 2008
• 卷：195
• 期：1-2
• 页码：146-150
• 文件大小：126 K

摘要

Some polymorphisms in the FCRL3 gene, a member of the Fc-receptor like family, have been associated with several autoimmune diseases and recently with multiple sclerosis (MS). We performed a case–control study of three SNPs in FCRL3 gene in 645 MS patients and 786 controls, all Caucasians from the South of Spain. Genotype and allele frequencies of two SNPs (rs7528684/FCRL3_3 and rs7522061/N28D), which were in high linkage disequilibrium (r² = 0.87), differed between MS cases and controls. The C allele of FCRL3_3 was found to be protective for MS (per allele OR = 0.81, 95%C.I. = 0.70–0.94; P-value = 0.007) as was the G variant of N28D, but no association was found for rs11264799/FCRL3_4. Haplotype analysis confirmed these associations with highly consistent effect sizes for haplotypes carrying the C allele of FCRL3_3.