Manganese superoxide dismutase in pathogenic fungi: An issue with pathophysiological and phylogenetic involvements
- 作者：Emilie Fré ; alle ; Christophe Noë ; l ; Eric Viscogliosi ; Daniel Camus ; Eduardo Dei-Cas and Laurence Delhaes
- 关键词：Fungi ; Antioxidant enzyme ; Phylogeny ; Pathogenicity ; Manganese superoxide dismutase
- 刊名：FEMS Immunology and Medical Microbiology
- 出版年：2005
- 期刊代码：32_09288244
- 类别：imm
- 出版时间：2005
- 卷：45
- 期：3
- 页码：411-422
- 文件大小：444 K
摘要
Manganese-containing superoxide dismutases (MnSODs) are ubiquitous metalloenzymes involved in cell defence against endogenous and exogenous reactive oxygen species. In fungi, using this essential enzyme for phylogenetic analysis of Pneumocystis and Ganoderma genera, and of species selected among Ascomycota, Basidiomycota and Zygomycota, provided interesting results in taxonomy and evolution. The role of mitochondrial and cytosolic MnSODs was explored in some pathogenic Basidiomycota yeasts (Cryptococcus neoformans var. grubii, Cryptococcus neoformans var. gattii, Malassezia sympodialis), Ascomycota filamentous fungi (Aspergillus fumigatus), and Ascomycota yeasts (Candida albicans). MnSOD-based phylogenetic and pathogenic data are confronted in order to evaluate the roles of fungal MnSODs in pathophysiological mechanisms.