Evaluation of endo- and exo-aryl-substitutions and central scaffold modifications on diphenyl substituted alkanes as 5-lipoxygenase activating protein inhibitors

详细信息	查看全文 | 推荐本文 |

• 作者：Lin Chu ; ^{lin_chu@merck.com} ; Helen M. Armstrong ; Linda L. Chang ; Amy F. Cheng ; Lawrence Colwell ; Jisong Cui ; Jilly Evans ; Amy Galka ; Mark T. Goulet^&dagger ; ; Nancy Hayes ; Jane Lo ; John Menke ; Hyun O. Ok ; Debra L. Ondeyka ; Minal Patel ; Grace M. Quaker ; Heather Sings^&Dagger ; ; Stephanie L. Witkin ; Annie Zhao ; Feroze Ujjainwalla
• 关键词：5-Lipoxygenase activating protein ; FLAP inhibitors ; Antiasthmatic
• 刊名：Bioorganic and Medicinal Chemistry Letters
• 出版年：2012
• 期刊代码：10_0960894x
• 类别：ch
• 出版时间：15 June, 2012
• 卷：22
• 期：12
• 页码：4133-4138
• 文件大小：3583 K

摘要

A search for a suitable replacement for the central norbornyl scaffold presented in the recently disclosed novel FLAP inhibitors is herein described, as well as the SAR study performed on the endo and exo-aryl groups.