Efficacy and safety of rosuvastatin 40 mg versus atorvastatin 80 mg in high-risk patients with hypercholesterolemia: Results of the POLARIS study

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• 作者：Lawrence A. Leiter ; Robert S. Rosenson ; Evan Stein ; John P.D. Reckless ; Karl-Ludwig Schulte ; Margo Schleman ; Paul Miller ; Michael Palmer ; Froukje Sosef
• 关键词：Hypercholesterolemia ; Rosuvastatin ; Atorvastatin ; Low-density lipoprotein cholesterol
• 刊名：Atherosclerosis
• 出版年：2007
• 期刊代码：28_00219150
• 类别：med
• 出版时间：October 2007
• 卷：194
• 期：2
• 页码：e154-e164
• 文件大小：280 K

摘要

POLARIS investigated the efficacy and safety of rosuvastatin 40 mg and atorvastatin 80 mg in high-risk patients with hypercholesterolemia. Patients (n = 871) were randomized to rosuvastatin 40 mg/day or atorvastatin 80 mg/day for 26 weeks. The primary endpoint was percentage change in LDL-C levels at 8 weeks. Secondary assessments included safety and tolerability, NCEP ATP III LDL-C goal achievement, change in other lipids and lipoproteins at 8 and 26 weeks, and health economics.

Mean LDL-C levels were reduced significantly more with rosuvastatin 40 mg than with atorvastatin 80 mg at 8 weeks (−56%versus −52%, p < 0.001). The proportion of patients achieving the NCEP ATP III LDL-C goal at 8 weeks was significantly higher in the rosuvastatin 40 mg group (80%versus 72%, p < 0.01). Significant differences in the change from baseline in high-density lipoprotein cholesterol (HDL-C) (+9.6%versus +4.4%) and apolipoprotein (Apo)A-I levels (+4.2 versus −0.5) were observed between rosuvastatin and atorvastatin (all p < 0.05). Both treatments were well tolerated. Based on a US analysis, rosuvastatin used fewer resources and delivered greater efficacy.

Intensive lipid-lowering therapy with rosuvastatin 40 mg/day provided greater LDL-C-lowering efficacy than atorvastatin 80 mg/day, enabling more patients to achieve LDL-C goals. Rosuvastatin may therefore improve LDL-C goal achievement in high-risk patients with hypercholesterolemia.