- 作者：Angel Salinas-Alamá ; n ; Alfredo Garcí ; a-Layana ; Miguel J. Maldonado ; Carmen Sainz-Gó ; mez and Aurora Alvá ; rez-Vidal
- 刊名：American Journal of Ophthalmology
- 出版年：2005
- 期刊代码：7_00029394
- 类别：med
- 出版时间：2005
- 卷：140
- 期：1
- 页码：23.e1-23.e7
- 文件大小：388 K
Purpose
To evaluate the role of optical coherence tomography (OCT) in determining choroidal neovascularization (CNV) activity before and after photodynamic therapy (PDT) in patients with age-related macular degeneration (ARMD).Design
Prospective observational case series.
Methods
setting: Institutional study. patient population: Fifty-three patients (62 eyes) with ARMD. observation procedure: Prospective observational case study. main outcome measures: Presence or absence of leakage on fluorescein angiography, presence of intraretinal or sub-retinal fluid on OCT, and macular and choroidal neovascular complex thickness on OCT.
Results
The macular thickness decreased significantly after PDT (P = .001). However, no significant changes in CNV thickness were measured after PDT (P = .567). Once the diagnosis of ARMD was established before treatment, OCT had a sensitivity of 96.77%for detecting CNV activity. After treatment, OCT had a good sensitivity (95.65%) and a moderate specificity (59.01%) in determining CNV activity, which resulted in a diagnostic efficiency (proportion of correct results) of 82.95%.
Conclusions
OCT appears to be useful for indicating CNV activity. Therefore, it may serve as a complementary technique for deciding the need for PDT and re-treatment in patients with ARMD.