摘要
DNAM-1 gene-deficient (鈭?鈭? mice take significantly longer to clear an acute and persistent LCMV infection in vivo than DNAM-1 +/+ mice. During acute LCMV priming, at the single cell level, DNAM-1 鈭?鈭?mice made significantly less cytoplasmic CD8 TNF-伪 and IL-2 but not IFN-纬 than their DNAM-1 +/+ counterparts. Restimulated immune memory CD8 T cells from DNAM-1 鈭?鈭?and DNAM-1 +/+ mice were equivalent in cytolytic activity against LCMV-infected target cells but DNAM-1 鈭?鈭?CD8 T cells had significant reductions in TNF-伪 and IL-2 that were associated on adoptive transfer with the inability to terminate the persistent viral infection.