Determinants of DHA levels in early infancy: Differential effects of breast milk and direct fish oil supplementation

详细信息	查看全文 | 推荐本文 |

• 作者：S.J. Meldrum^a ; ^b ; ^{smeldrum@meddent.uwa.edu.au} ; N. D'Vaz^a ; Y. Casadio^c ; J.A. Dunstan^a ; N. Niels Krogsgaard-Larsen^d ; K. Simmer^a ; ^b ; S.L. Prescott^a
• 关键词：AA ; Arachidonic Acid (20 ; 4n&minus ; 6) ; DHA ; Docosahexaenoic Acid (22 ; 6n&minus ; 3) ; EPA ; Eicosapentaenoic Acid (20 ; 5n&minus ; 3) ; (LC) PUFA ; (Long-Chain) Polyunsaturated Fatty Acids ; n&minus ; 3 ; Omega 3 ; n-6 ; Omega-6
• 刊名：Prostaglandins ; Leukotrienes and Essential Fatty Acids (PLEFA)
• 出版年：2012
• 期刊代码：32_09523278
• 类别：bio
• 出版时间：June, 2012
• 卷：86
• 期：6
• 页码：233-239
• 文件大小：368 K

摘要

Introduction

Although omega (n)-3 long-chain polyunsaturated fatty acids (LCPUFA), particularly docosahexaenoic acid (DHA), intakes are important during infancy, the optimal method of increasing infant status remains unclear. We hypothesized that high-dose infant fish oil supplementation would have greater relative effects upon n-3 LCPUFA status at six months of age than breast milk fatty acids.

Patients and methods

Infants (n=420) were supplemented daily from birth to six months with fish oil or placebo. In a subset of infants, LCPUFA levels were measured in cord blood, breast milk and in infant blood at 6 months.

Results

DHA levels increased in the fish oil group relative to placebo (p<05). Breast milk DHA was the strongest predictor of infant erythrocyte DHA levels (p=<001). This remained significant after adjustment for cord blood DHA, supplementation group and adherence.

Conclusion

In this cohort, breast milk DHA was a greater determinant of infant erythrocyte n鈭? LCPUFA status, than direct supplementation with fish oil.