Preparation of aqueous dispersions of coenzyme Q₁₀ nanoparticles with amylomaize starch and its dextrin

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• 作者：Eun-Ah Kim^a ; Jong-Yea Kim^a ; Hyun-Jung Chung^b ; Seung-Taik Lim^a ; ^{limst@korea.ac.kr}
• 关键词：Coenzyme Q10 ; Nano-dispersion ; High amylose maize starch ; Dextrin ; Dispersion stability
• 刊名：Lebensmittel-Wissenschaft und -Technologie
• 出版年：2012
• 期刊代码：121_00236438
• 类别：abs
• 出版时间：July, 2012
• 卷：47
• 期：2
• 页码：493-499
• 文件大小：297 K

摘要

An aqueous dispersion of CoQ₁₀ nanoparticles could be prepared by using amylomaize starch or its dextrin (average DP 311). CoQ₁₀ (100聽mg dry solids) was dispersed in aqueous starch or dextrin solution (500聽mg/5聽mL) at 60-80聽掳C for 3聽days, and then the solids were isolated by centrifuging in the dispersion (25,000脳 g, 30聽min). The isolated particles consisted of CoQ₁₀ and starch at an approximate weight ratio of 2:1. The presence of V-amylose complex with CoQ₁₀ was confirmed under differential scanning calorimetery (DSC), but most of the CoQ₁₀ in the particles existed as crystalline aggregates. The isolated particles, initially ranged in micrometer, could be re-dispersed in water at nano-sizes by treating with a mild ultrasonication. The aqueous dispersions of CoQ₁₀ nanoparticles (100聽mg/100聽g) exhibited zeta potentials of聽鈭?3.9 and聽鈭?1.1聽mV, respectively for starch and dextrin dispersions, and remained homogeneous for more than 3聽weeks without forming precipitates during an ambient storage.