Correlation and Agreement Between Contrast-Enhanced Ultrasonography and Perfusion Computed Tomography for聽Assessment of Liver Metastases from Endocrine Tumors:聽Normalization Enhances Correlation
- 作者：Thibaud Lefort&lowast ; ; Frank Pilleul&lowast ; ; Sé ; bastien Mulé ; &dagger ; ; S. Lori Bridal&Dagger ; ; Fré ; dé ; rique Frouin&dagger ; ; Catherine Lombard-Bohas§ ; ; Thomas Walter§ ; ; Olivier Lucidarme&Dagger ; ; ¶ ; ; Aymeric Guibal&lowast ; ; &dagger ; ; aymeric.guibal@gmail.com
- 关键词：Contrast-enhanced ultrasonography ; Microbubbles ; Perfusion imaging ; Functional imaging ; Biomarkers ; Angiogenesis ; Liver ; Endocrine tumor ; Metastasis
- 刊名：Ultrasound in Medicine and Biology
- 出版年：2012
- 期刊代码：82_03015629
- 类别：ph
- 出版时间：June, 2012
- 卷：38
- 期：6
- 页码：953-961
- 文件大小：891 K
摘要
We studied correlation and agreement between perfusion parameters derived from contrast-enhanced ultrasonography (CEUS) and computed tomography (CT). Both techniques were performed in 16 patients with proven liver metastases from endocrine tumor. Replenishment study after ultrasound-induced destruction of microbubbles was used for CEUS quantification. CEUS-derived relative values of blood flow, blood volume and mean transit time were compared with perfusion CT-derived parameters measured in the same tumors. Significant correlation was observed between CEUS normalized values and CT absolute tumor values for blood flow (r聽= 0.58; p聽= 0.018), blood volume (r聽= 0.61; p聽= 0.012) and mean transit time (r聽= 0.52; p聽= 0.037). Correlation was not significant for non-normalized values. Agreement between CEUS normalized values and perfusion CT relative values was significant (p < 0.04). Estimated bias between CEUS and CT for relative perfusion values was 鈭?.38 (鈭?.02; 2.27) for blood flow,聽+0.26 (鈭?.79; 1.31) for blood volume and聽+0.21 (鈭?.46; 0.87) for mean transit time. We conclude that normalization markedly increased correlation between CEUS- and CT-derived perfusion values and allowed agreement assessment.