Leishmaniasis: Vaccine candidates and perspectives
- 作者：Bhawana Singh ; Shyam Sundar ; drshyamsundar@hotmail.com
- 关键词：VL ; visceral leishmaniasis ; IFN ; interferon ; IL ; interleukin ; CTL ; cytotoxic T lymphocyte ; CL ; cutaneous leishmaniasis ; CVL ; canine visceral leishmaniasis ; MPL-SE ; monophosphoryl lipid A soluble emulsion ; PV ; parasitophorous vacuole ; NET ; neutrophil extra
- 出版年：2012
- 期刊代码：89_0264410x
- 类别：imm
- 出版时间：6 June, 2012
- 卷：30
- 期：26
- 页码：3834-3842
- 文件大小：426 K
摘要
Leishmania is a protozoan parasite and a causative agent of the various clinical forms of leishmaniasis. High cost, resistance and toxic side effects of traditional drugs entail identification and development of therapeutic alternatives. The sound understanding of parasite biology is key for identifying novel drug targets, that can induce the cell mediated immunity (mainly CD4+ and CD8+ IFN-gamma mediated responses) polarized towards a Th1 response. These aspects are important in designing a new vaccine along with the consideration of the candidates with respect to their ability to raise memory response in order to improve the vaccine performance. This review is an effort to identify molecules according to their homology with the host and their ability to be used as potent vaccine candidates.