Bed nucleus of the stria terminalis and the cardiovascular responses to chemoreflex activation

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• 作者：&Eacute ; rica M. Granjeiro^a ; ¹ ; Felipe V. Gomes^b ; ¹ ; Fernando H.F. Alves^b ; Carlos C. Crestani^c ; Fernando M.A. Corr&ecirc ; a^b ; Leonardo B.M. Resstel^b ; ^{leoresstel@yahoo.com.br}
• 关键词：ACSF ; Artificial Cerebrospinal Fluid ; BNST ; Bed nucleus of stria terminalis ; CoCl2 ; cobalt chloride ; HR ; heart rate ; IL ; infralimbic cortex ; KCN ; potassium cyanide ; MAP ; mean arterial pressure ; NTS ; nucleus of the tractus solitarius ; PAP ; pulsatile arteri
• 刊名：Autonomic Neuroscience
• 出版年：2012
• 期刊代码：31_15660702
• 类别：med
• 出版时间：3 April, 2012
• 卷：167
• 期：1-2
• 页码：21-26
• 文件大小：639 K

摘要

Several studies from our group have indicated that the BNST play an important role in baroreflex modulation. However, the involvement of the BNST in the chemoreflex activity is unknown. Thus, in the present study, we investigated the effect of the local bed nucleus of stria terminalis (BNST) neurotransmission inhibition by bilateral microinjections of the non-selective synaptic blocker cobalt chloride (CoCl₂) on the cardiovascular responses to chemoreflex activation in rats. For this purpose, chemoreflex was activated with KCN (i.v.) before and after microinjections of CoCl₂ into the BNST. Reversible BNST inactivation produced no significant changes in the magnitude and durations of both pressor and bradycardic responses to intravenous KCN infusion. These findings suggesting that BNST neurotransmission have not influence on both sympathoexcitatory and parasympathoexcitatory components of the peripheral chemoreflex activation.