Parkinsonian signs and symptoms in adults with a history of Sydenham鈥檚 chorea

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• 作者：Leonardo Brandã ; o Barreto ; Ricardo Oliveira Horta Maciel ; Dé ; bora P. Maia ; Antonio Lú ; cio Teixeira ; Francisco Cardoso ; ^{cardosofe@terra.com.br}
• 关键词：Sydenham&rsquo ; s chorea ; Chorea ; Parkinsonism ; Bradykinesia
• 刊名：Parkinsonism and Related Disorders
• 出版年：2012
• 期刊代码：215_13538020
• 类别：med
• 出版时间：June, 2012
• 卷：18
• 期：5
• 页码：595-597
• 文件大小：113 K

摘要

Background

Sydenham鈥檚 chorea is associated with dysfunction of fronto-striatal circuits induced by cross-reactive antibodies to group A 尾-hemolytic streptococcus. High susceptibility of extrapyramidal effects of neuroleptics in patients with Sydenham鈥檚 chorea suggests underlying nigro-striatal dysfunction.

Objective

To study the presence of parkinsonism in patients with a history of Sydenham鈥檚 Chorea.

Methods

We used the UFMG Sydenham鈥檚 Chorea Rating Scale (USCRS) and the Unified Parkinson鈥檚 Disease Rating Scale (UPDRS) part III, respectively, to determine the presence of chorea and parkinsonian symptoms and signs in 25 adults with a history of previous Sydenham鈥檚 Chorea currently without chorea or use of anti-choreic drugs.

Results

Bradykinesia was found in 64%of subjects. There was a statistically significant correlation between bradykinesia and hemichorea (鈭?.412; p聽=聽0.036) and bradykinesia and generalized chorea (0.412; p聽=聽0.036). There was no correlation between bradykinesia and use of anti-choreic drugs.

Conclusions

Bradykinesia is common in patients with Sydenham鈥檚 Chorea in remission. This finding suggests an immune-mediated dysfunction of the nigro-striatal system.