Leptine et grossesse : dogmes, questions et perspectives
- 作者：J. Lepercq ; P. Catalano ; S. Hauguel de Mouzon
- 关键词：Leptin ; Pregnancy ; Metabolism
- 刊名：Gynecology Obstetrique & Fertilite
- 出版年：2007
- 期刊代码：108_12979589
- 类别：med
- 出版时间：February 2007
- 卷：35
- 期：2
- 页码：89-95
- 文件大小：362 K
摘要
Leptin has been primarily considered as a protein secreted by the adipocyte and a regulator of satiety and energy homeostasis. A role for leptin in pregnancy was later suggested as circulating levels of leptin are high in the pregnant woman and leptin is synthetized within the placenta. Placental leptin production is increased in various obstetrical conditions associated with alterations of fetal growth (diabetes, preeclampsia). Furthermore, umbilical leptin can be viewed as a biomarker of fetal adiposity. Our aim is to review the putative roles of leptin in pregnancy.