The effects of a new human leukocyte elastase inhibitor (recombinant guamerin) on cerulein-induced pancreatitis in rats
- 作者：Yun Ju Jo ; Ho Soon Choi ; Dae Won Jun ; Oh Young Lee ; Joo Seop Kang ; Il Gyu Park ; Kyung Hwan Jung ; Joon Soo Hahm
- 关键词：Leukocyte elastase inhibitor ; Guamerin ; Pancreatitis ; Interleukin-6 ; Tumor necrosis factor-
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- 刊名：International Immunopharmacology
- 出版年：2008
- 期刊代码：123_15675769
- 类别：med
- 出版时间：July 2008
- 卷：8
- 期：7
- 页码：959-966
- 文件大小：579 K
摘要
Pancreatic and neutrophil elastase can aggravate or induce acute pancreatitis. Although increased elastase levels in the plasma of pancreatitis patients and animal models have been reported, the mechanism by which elastase is involved in the pathogenesis of acute pancreatitis has not yet been elucidated. We aimed to investigate the effects and the possible mechanism of a new human leukocyte elastase inhibitor (recombinant guamerin) in the treatment of cerulein-induced acute pancreatitis in rats.