Inflammatory bowel disease and pregnancy: overlapping pathways
- 作者：Noha Ahmed Nasef ; Lynnette R. Ferguson ; l.ferguson@auckland.ac.nz
- 关键词：15-PGJ ; 15-deoxy-delta-12 ; 14-prostaglandin J2 ; AA ; arachidonic acid ; CD ; Crohn disease ; COX ; cyclooxygenase ; CSF ; colony stimulating factor ; DSS ; dextran sodium sulfate ; EP ; prostaglandin E2 receptor ; HLA ; human leukocyte antigen ; IBD ; inflammatory bowel
- 刊名：Translational Research
- 出版年：2012
- 期刊代码：340_19315244
- 类别：med
- 出版时间：July, 2012
- 卷：160
- 期：1
- 页码：65-83
- 文件大小：761 K
摘要
Several studies have reported on the association between inflammatory bowel disease (IBD) and adverse pregnancy outcomes, such as preterm birth. The exact mechanisms of action are unclear; however, several pathways and processes are involved in both IBD and pregnancy that may help explain this. In this review, we discuss the immune system's T helper cells and human leukocyte antigens, inflammation, its function, and the role of Toll-like receptors (TLRs), NOD-like receptors (NLRs), and prostaglandins in the inflammatory response. For each of these topics, we consider their involvement in IBD and pregnancy, and we speculate as to how they can lead to preterm birth. Finally, we review briefly corticosteroids, biologic therapies, and immunosuppressants for the treatment of IBD, as well as their safety in use during pregnancy, with special focus on preterm birth.