- 作者：Muhei Tanaka ; M.D.a ; Michiaki Fukui ; M.D. ; Ph.D.a ; sayarinapm@hotmail.com ; Masaaki Kuroda ; M.D. ; Ph.D.b ; Masahiro Yamazaki ; M.D. ; Ph.D.a ; Goji Hasegawa ; M.D. ; Ph.D.a ; Yohei Oda ; M.D. ; Ph.D.a ; Yuji Naito ; M.D. ; Ph.D.c ; Hitoshi Toda ; M.D. ; Ph.D.d ; Toshikazu Yoshikawa ; M.D. ; Ph.D.c ; Naoto Nakamura ; M.D. ; Ph.D.a
- 关键词：Pepsinogen ; Glucose ; Triacylglycerol ; Uric acid ; Atrophic gastritis
- 刊名：Nutrition
- 出版年：2012
- 期刊代码：81_08999007
- 类别：abs
- 出版时间：April, 2012
- 卷：28
- 期：4
- 页码：418-421
- 文件大小：174 K
Objective
Under- and overnutrition are associated with a worse prognosis and constitute independent risk factors for morbidity and mortality. It is increasingly important to understand the factors that affect nutritional and metabolic statuses. The purpose of this study was to assess the relation between the pepsinogen I/II ratio and several biochemical markers.Methods
A cross-sectional study was performed in 1985 subjects who underwent a health screening test. Subjects had no medications for hyperuricemia, dyslipidemia, diabetes mellitus, or hypertension. All subjects were classified into two groups. Subjects with a pepsinogen I/II ratio below 3 were defined as having atrophic gastritis. The relations between the pepsinogen I/II ratio and several biochemical markers, including total cholesterol, triacylglycerol, uric acid, cholinesterase, and glucose levels, were evaluated.
Results
The presence of atrophic gastritis was significantly associated with age, smoking status, alcohol consumption, body mass index, and triacylglycerol, uric acid, cholinesterase, and hemoglobin levels. Multiple linear regression analysis demonstrated that the pepsinogen I/II ratio was an independent determinant of glucose level (尾 = 0.104, P < 0.0001), triacylglycerol level (尾 = 0.072, P聽= 0.0014), uric acid level (尾 = 0.048, P = 0.0138), and hemoglobin (尾 = 0.037, P = 0.0429) after adjustments for age, sex, smoking status, alcohol consumption, and body mass index.
Conclusion
The pepsinogen I/II ratio was related to glucose, triacylglycerol, and uric acid levels. Such an association fosters the idea that a decreased pepsinogen I/II ratio seems favorable for the prevention of overnutrition.