Long-term effects on left ventricular function after late thrombolysis in patients with myocardial infarction
- 作者：Liguori ; Antonio ; di Gregorio ; Fernando ; Leccese ; Maurizio ; Montemarano ; Angelo ; Di Ieso ; Nicola ; et. al.
- 关键词：thrombolysis ; myocardial infarction ; regional function ; left ventricular function ; myocardial ischemia.
- 刊名：Current Therapeutic Research
- 出版年：1997
- 期刊代码：75_0011393x
- 类别：med
- 出版时间：September, 1997
- 卷：58
- 期：9
- 页码：570-574
- 文件大小：388 K
摘要
This open-label, uncontrolled, retrospective study assessed the long-term effects of late thrombolysis on left ventricular (LV) function. We studied 79 patients (52 men and 27 women; mean age, 51 ± 5 years) treated with alteplase (group 1) and 46 patients (33 men and 13 women; mean age, 52 ± 8 years) treated with heparin alone (group 2) at their first myocardial infarction (MI). Patients were eligible for the study if they were younger than 62 years, their duration of pain was longer than 6 hours, and they had no episodes of angina in the 48 hours preceding their MI. The peak of creatine kinase-muscle and brain subunits was significantly less in group 1 than group 2 (106 ± 67 vs 205 ± 102 IU/L). Both LV ejection fraction and wall-motion score were better in thrombolysed patients, and the cumulative frequency of radionuclide defects was higher in these patients during the 4-year follow-up. Our study supports the concept that thrombolysis reduces the incidence of long-term post-MI residual ischemia, improving global LV function even when given late after the onset of MI symptoms.