• 作者：B. Tarazona^a ; ^{belimed22@hotmail.com} ; W. Ramos^b ; J. Arce^a ; J. Yarinsueca^b ; ^c ; S. Morales^d ; G. Ronceros^b ; ^c ; C. Galarza^b ; ^c ; J. Pé ; rez^b ; ^c
• 关键词：Isquemia cerebral ; Adultos j&oacute ; venes ; Factores de riesgo ; Perú
• 刊名：Neurolog铆a
• 出版年：2010
• 期刊代码：pca262_02134853
• 类别：med
• 出版时间：October 2010
• 卷：25
• 期：8
• 页码：470-477
• 文件大小：132 K

Introduction

To determinate the etiology and risk factors for a first episode of cerebral ischemia in young adults at three hospitals of Lima and Callao-Peru.

Methods

Multicentric study carried out at three national hospitals in Lima. The sample included 30 patients with a first episode of stroke and 60 controls matched by age and sex 2:1 with the patients. Serum biochemistry studies, EKGs and echocardiograms were done. Etiologies were classified based on the classification of Baltimore-Washington Cooperative Young Stroke Study.

Results

The most frequent etiologies were cardiac embolism and atherosclerotic valvular heart disease, which were 30%of the cases (9 patients) each one. Hypertriglyceridemia (p = 0.014), valvular heart disease (p = 0.001) and hormonal contraception/replacement therapy (p = 0.002) were independent risk factors for a first episode of cerebral ischemia in peruvian young adults. Motor deficiency was the most frequent presentation (50.0%). Intracraneal hypertension and urinary tract infection were the most frequent complications during acute ischemia and mortality was raised up to 10%.

Conclusions

The hypertriglyceridemia, valvular heart disease and the use of oral contraceptives are independent risk factors for a first episode of ischemia in young adults from three hospitals of Lima and Callao. The most frequent etiologies were cardiac embolism and atheroesclerotic valvular heart disease.