• 作者：Christopher Torres^a ; Marcos M. Lima-Martí ; nez^b ; ^{marcoslimamedical@hotmail.com} ; Francisco J. Rosa^a ; Ernesto Guerra^a ; Mariela Paoli^b ; Gianluca Iacobellis^c ; Marianela Rodney^d ; Eduardo Romero-Vecchione^e ; Maria Luisa Saadtjian^f ; Moisé ; s Zagala^d ; Henry Rodney^d
• 关键词：Tejido adiposo epicá ; rdico ; Adrenomedulina ; Aterosclerosis ; Sí ; ndrome metab&oacute ; lico
• 刊名：Endocrinolog铆a y Nutrici贸n
• 出版年：2011
• 期刊代码：pca151_15750922
• 类别：med
• 出版时间：October 2011
• 卷：58
• 期：8
• 页码：401-408
• 文件大小：283 K

Objective

To assess the association between epicardial adipose tissue thickness (EAT) and plasma adrenomedullin plasma levels in patients with metabolic syndrome (MS).

Methods

Twenty-one patients (12 females and 9 males) with MS according to the International Diabetes Federation guidelines, aged 22-58 years, were enrolled into the study and compared to 19 age-matched control subjects without MS. Plasma glucose, lipid, and adrenomedullin levels were assessed. EAT, left ventricular mass, and carotid intima-media thickness were evaluated by transthoracic two-dimensional echocardiography.

Results

No statistically significant differences were found between the groups in age, sex, and height. Body weight, abdominal circumference (AC), body mass index (BMI), systolic blood pressure (SBP), and diastolic blood pressure (DBP) were significantly higher (p = 0.0001) in MS patients; this group also showed significantly higher glucose (p = 0.001), total cholesterol (p = 0.01), LDL-C (p = 0.03), VLDL-C (p = 0.005), triglyceride (p = 0.002), Tg/HDL ratio (p = 0.0001), and plasma adrenomedullin (3.49 卤 1.21 vs 1.69 卤 0.92 ng/mL; p = 0.0001) levels and lower HDL-C (p = 0.02) levels as compared to the control group. EAT was significantly thicker in MS patients compared to the control group (8.45 卤 3.14 vs 5.43 卤 0.96; p = 0.0001), showed a positive correlation to BMI (r = 0.347; p = 0.02), AC (r = 0.350; p = 0.02), DBP (r = 0.346; p = 0.02), and adrenomedullin levels (r = 0.741; p = 0.0001). In multiple linear regression analysis, adrenomedullin was the only parameter associated to EAT (R² = 0.550; p = 0.0001).

Conclusion

In this small patient group, a statistically significant association was found between EAT and plasma adrenomedullin levels, which may be considered as a potential biomarker of MS.