Highly efficient, one-pot, solvent-free synthesis of tetrasubstituted imidazoles using HClO4–SiO2 as novel heterogeneous catalyst
- 作者：Srinivas Kantevari ; Srinivasu V.N. Vuppalapati ; Dhanraj O. Biradar ; Lingaiah Nagarapu
- 关键词：Imidazoles ; Four-component reaction ; One-pot synthesis ; MCRs ; Silica-supported perchloric acid
- 刊名：Journal of Molecular Catalysis A ; Chemical
- 出版年：2007
- 期刊代码：57_13811169
- 类别：ch
- 出版时间：2 April 2007
- 卷：266
- 期：1-2
- 页码：109-113
- 文件大小：182 K
摘要
Highly efficient, one-pot, four-component synthesis of 1,2,4,5-tetrasubstituted imidazoles was reported the condensation of various aldehydes, benzil, aliphatic or aromatic primary amines and ammonium acetate under solvent free conditions using perchloric acid adsorbed on silica gel (HClO4–SiO2) as catalyst in excellent yields. HClO4–SiO2 exhibited remarkable catalytic activity with respect to the reaction time (2–20 min), amount of catalyst. Present protocol with HClO4–SiO2 catalyst is convincingly superior to the recently reported catalytic methods.