CR3-dependent negative regulation of human eosinophils by Mycobacterium bovis BCG lipoarabinomannan

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• 作者：Virginie Driss^a ; ^e ; Emmanuel Hermann^a ; ^f ; ^g ; Fanny Legrand^a ; ^h ; Sylvie Loiseau^a ; ^h ; Marie Delbeke^a ; ^h ; Laurent Kremer^b ; ^c ; Yann Guerardel^d ; David Dombrowicz^a ; ⁱ ; Monique Capron^a ; ^h ; ^{monique.capron@univ-lille2.fr}
• 关键词：Eosinophil ; Complement receptor ; Mycobacterium ; Lipoarabinomannan ; Innate immunity
• 刊名：Immunology Letters
• 出版年：2012
• 期刊代码：115_01652478
• 类别：med
• 出版时间：30 April, 2012
• 卷：143
• 期：2
• 页码：202-207
• 文件大小：618 K

摘要

Eosinophils have recently been shown to participate in innate immune responses against mycobacteria. We have investigated whether Mycobacterium bovis BCG regulate the human eosinophil immune response. A negative correlation between mycobacteria internalization and eosinophil activation was observed. In addition, mannose-capped lipoarabinomannan from M. bovis BCG (ManLAM) failed to induce a significant release of eosinophil peroxidase and TNF-伪. Noteworthy, ManLAM exhibited a potent inhibitory effect on eosinophil peroxidase release by TLR2-activated eosinophils involving the complement receptor-3 molecule and the phosphatidylinositol-3 kinase pathway. ManLAM, generally present in pathogenic mycobacteria, plays an important role in modulating eosinophil-dependent immune response.