15-Lipoxygenase-2 expression in human macrophages induces chemokine secretion and T cell migration

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• 作者：Kristina Noré ; n Danielsson ; Ellen Knutsen Rydberg ; Madeleine Ingelsten ; Levent M. Akyü ; rek ; Pernilla Jirholt ; Christina Ullströ ; m ; Gun-Britt Forsberg ; Jan Boré ; n ; Olov Wiklund ; Lillemo
• 关键词：Macrophages ; 15-Lipoxygenase-2 ; Chemokines ; Migration ; T cells ; Atherosclerosis
• 刊名：Atherosclerosis
• 出版年：2008
• 期刊代码：28_00219150
• 类别：med
• 出版时间：July 2008
• 卷：199
• 期：1
• 页码：34-40
• 文件大小：377 K

摘要

We determined previously that hypoxia results in increased 15-lipoxygenase type 2 (15-LOX-2) expression and CXCL8 secretion in macrophages. This study sought to determine whether 15-LOX-2 expression links directly with the secretion of inflammatory molecules in macrophages and also investigated its subsequent effects on T cell migration.