The 9p21 genetic variant is additive to carotid intima media thickness and plaque in improving coronary heart disease risk prediction in white participants of the Atherosclerosis Risk in Communities (ARIC) Study

详细信息	查看全文 | 推荐本文 |

• 作者：Vijay Nambi^a ; ^{vnambi@bcm.tmc.edu} ; Eric Boerwinkle^b ; Kim Lawson^b ; Ariel Brautbar^a ; Lloyd Chambless^c ; Nora Franeschini^d ; Kari E. North^d ; Salim S. Virani^a ; ^e ; Aaron R. Folsom^f ; Christie M. Ballantyne^a
• 关键词：Carotid intima media thickness ; Plaque ; 9p21 ; Risk prediction ; Coronary heart disease
• 刊名：Atherosclerosis
• 出版年：2012
• 期刊代码：28_00219150
• 类别：med
• 出版时间：May, 2012
• 卷：222
• 期：1
• 页码：135-137
• 文件大小：161 K

摘要

Objective

We evaluated whether the addition of carotid intima media thickness and plaque (CIMT-P), and a single nucleotide polymorphism on chromosome 9p21 (9p21) together improve coronary heart disease (CHD) risk prediction in the ARIC study.

Methods

Ten year CHD risk was estimated using the ARIC coronary risk score (ACRS) alone and in combination with CIMT-P and 9p21 individually and together in White participants (n = 9338). Area under the receiver operating characteristic curve (AUC), model calibration, net reclassification index (NRI), integrated discrimination index (IDI) and number of individuals reclassified were estimated.

Results

The AUC of the ACRS, ACRS + 9p21, ACRS + CIMT-P and ACRS + CIMT-P + 9p21 models were 0.748, 0.751, 0.763 and 0.766 respectively. The percentage of individuals reclassified, model calibration, NRI and IDI improved when CIMT-P and 9p21 were added to the ACRS only model (see manuscript).

Conclusion

Addition of 9p21 allele information to CIMT-P minimally improves CHD risk prediction in whites in the ARIC study.