- 作者：Graziana Lupattelli ; glupa@unipg.it ; Donatella Siepi ; Stefano De Vuono ; Anna Rita Roscini ; Federica Crisanti ; Domenico Covelli ; Matteo Pirro ; Elmo Mannarino
- 关键词：Non-cholesterol sterols ; Statins ; Polygenic hypercholesterolemia ; Familial combined hyperlipemia
- 刊名：Life Sciences
- 出版年：2012
- 期刊代码：62_00243205
- 类别：imm
- 出版时间：6 June, 2012
- 卷：90
- 期：21-22
- 页码：846-850
- 文件大小：157 K
Aim
Non-cholesterol sterols reflect cholesterol metabolism. Statins reduce cholesterol synthesis usually with a rise in cholesterol absorption. Common hyperlipemias have shown different patterns of cholesterol metabolism. We evaluated whether cholesterol absorption and synthesis may differ after statin therapy in primary hyperlipemias.Main methods
We determined lipid profile, apoprotein B and serum sterols (lathosterol, sitosterol, campesterol by gas chromatography/mass spectrometry) before and after statins in 80 untreated hyperlipemic patients, 40 with polygenic hypercholesterolemia (PH) and 40 with familial combined hyperlipemia (FCH).
Key findings
At baseline in FCH lathosterol was significantly higher while campesterol and sitosterol were significantly lower than in PH. After statins, the reduction in LDL-C did not significantly differ between the two groups; in PH there was a significant decrease of lathosterol from 96.1 to 52.6 102 渭mol/mmol cholesterol (p = 0.0001) with no significant modifications in campesterol and sitosterol; on the opposite, in FCH lathosterol decreased from 117 to 43 102 渭mol/mmol cholesterol (p = 0.0001) and campesterol and sitosterol significantly increased from 38 to 48 102 渭mol/mmol cholesterol (p = 0.0001), and from 75 to 86 102 渭mol/mmol cholesterol, (p = 0.022), respectively. After statin therapy only in FCH 螖-LDL-C showed a significant inverse correlation with 螖-sitosterol and with 螖-campesterol.
Significance
Primary hyperlipemias show different patterns of response to statins: in PH LDL reduction appears completely 鈥渟ynthesis inhibition鈥?dependent, while in FCH LDL decrease appears to be synthesis dependent, partially limited by absorption increase. Studying cholesterol metabolism before and after hypolipemic therapy might be useful in identifying the best tailored treatment.