Super-micro-bland particle embolization combined with RF-ablation: Angiographic, macroscopic and microscopic features in porcine kidneys

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• 作者：C.M. Sommer^a ; ^{christof.sommer@med.uni-heidelberg.de} ; ^{cmsommer@gmx.com} ; N. Kortes^a ; C. Mogler^b ; N. Bellemann^a ; M. Holzschuh^a ; F. Arnegger^c ; F. Nickel^c ; T. Gehrig^c ; S. Zelzer^d ; H.P. Meinzer^d ; T. Longerich^b ; U. Stampfl^a ; H.U. Kauczor^a ; B.A. Radeleff^a
• 关键词：Radiofrequency ablation ; Embolization ; Particles ; Embozene ; Kidney
• 刊名：European Journal of Radiology
• 出版年：2012
• 期刊代码：93_0720048x
• 类别：med
• 出版时间：June, 2012
• 卷：81
• 期：6
• 页码：1165-1172
• 文件大小：913 K

摘要

Purpose

To describe angiographic, macroscopic and microscopic features of super-micro-bland particle embolization in combination with RF-ablation in kidneys. Thereby, a special focus was given on the impact of the sequence of the different procedural steps.

Materials and methods

In ten pigs, super-micro-bland particle embolization combined with RF-ablation was carried out. Super-micro-bland embolization was performed with spherical particles of very small size and tight calibration (40 卤 10 渭m). In the left kidneys, RF-ablations were performed before embolization (I). In the right kidneys, RF-ablations were performed after embolization (II). The animals were killed three hours after the procedures. Angiographic (e.g. vessel architecture), macroscopic (e.g. long and short axes of the RF-ablations) and microscopic (e.g. particle distribution) study goals were defined.

Results

Angiography detected almost no vessels in the center of the RF-ablations in I. In II, angiography could not define the RF-ablations. Macroscopy detected significantly larger long and short axes of the RF-ablations in II compared to I (52.2 卤 3.2 mm vs. 45.3 卤 6.9 mm [P < 0.05] and 25.1 卤 3.5 mm vs. 20.0 卤 1.9 mm [P < 0.01], respectively). Microscopy detected irregular particle distribution at the rim of the RF-ablations in I. In II, microscopy detected homogeneous particle distribution at the rim of the RF-ablations. Microscopy detected no particles in the center of the RF-ablations in I and II.

Conclusion

The sequence of the different procedural steps of super-micro-bland particle embolization combined with RF-ablation impacts angiographic, macroscopic and microscopic features in kidneys in the acute setting.