La reestenosis en el stent depende del da帽o vascular inducido. 驴Son v谩lidos los modelos experimentales actuales de an谩lisis de los stents farmacoactivos?
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摘要

ass="h4">Introduction and objectives

Drug-eluting stents are useful for preventing restenosis, but the patho-physiological processes involved in the proliferative response after implantation are still not known in detail. The aim of this study is to compare the coronary vascular histomorphometry after implanting drug-eluting stents and bare metal stents in a swine model.

ass="h4">Methods

Sixty stents were randomly implanted in 20 Large White female pigs with a ratio of baremetal/drug-eluting stents of 1:2. After 28 days, euthanasia and histomorphometry were performed. We defined the vessel injury score in accordance to whether the internal elastic lamina was intact or ruptured.

ass="h4">Results

There were no differences between drug-eluting stents and bare metal stents in the intact internal elastic lamina group regarding neointimal area or%restenosis (1.3 [1.1-2.2]) vs 2.0 [1.3-2.5] mm2; P=.6; and 14.0 [12.1-20.8] vs 22.2 [14.1-23.3]%; P=.5). We assessed statistically significant differences for the ruptured internal elastic lamina group, (neointimal area 1.2 [0.8-2.0] vs 2.9 [2.3-3.7] mm2; P=.001 and%restenosis 16.63 [11.2-23.5] vs 30.4 [26.4-45.7]%; P=.001).

ass="h4">Conclusions

In our swine model, we did not find any differences between proliferative response of drug-eluting stents and bare metal stents when the internal elastic lamina is intact; differences are only found when vascular injury is deeper.

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