- 作者：Lucas Martí ; n Romano ; lucasromano@hotmail.com ; lucasmartin.romano@gmail.com ; Esteban Spadaro ; Leandro Sousa ; Griselda Castellino ; Juan Pablo Zorrila ; Facundo Latini ; Pablo Á ; lvarez Abut ; Pablo Ioli ; Sergio Eduardo Gonorazky
- 关键词：Status epilé ; ptico ; Incidencia ; Mortalidad ; Argentina
- 刊名：Neurolog铆a Argentina
- 出版年：2011
- 期刊代码：pca377_18530028
- 类别：neu
- 出版时间：January-March 2011
- 卷：3
- 期：1
- 页码：18-25
- 文件大小：470 K
Introduction
Although status epilepticus (SE) is one of the higher incidence of neurological emergencies, no epidemiological data are available in Latin America, including Argentina.
Objectives
To determine the crude annual incidence rate, the specific rates according to age and sex based on the Official Argentinian National Census (OANC) of 2001, and the 30-day case fatality of a first episode of SE in adults.
Material and methods
Our institution, the Hospital Privado de Comunidad de Mar del Plata, Argentina, attends a captive population of 60.912 exclusively and completely. We prospectively examined the population-based, crude, and the corrected, age-adjusted, age- and sex-specific incidences of a first episode of SE in adults 鈮?1 years, in the state of Mar del Plata, Argentina, from April 2007 through March 2009.
Results
The crude annual incidence rate was 56.6 SE/100.000 (95%IC, 44.1鈥?1.7), 61.2 in men (95%IC, 40鈥?9.7) and 54.1 in women (95%IC, 41.4鈥?0.4). The incidence was higher in the elderly than in younger adults (>60 years: 66/100,000 vs 鈮?0 years: 22.6/100,000, p<0.008). The adjusted annual rate to OANC was 24.3 SE/100.000. Acute symptomatic SE were most frequent etiology (73%) due to cerebrovascular disease (34%). There was a similar frequency of convulsive (52%) and non-convulsive SE (48%). Epilepsy was previouslydiagnosed in 30%of the patients. The case-fatality rate was 36%.
Conclusions
The data presented, to our knowledge, is the first prospective epidemiological study conducted in Argentina and Latin America showing higher incidence rates than those observed in previous studies in developed countries, possibly suggesting an increased risk of SE in developing countries. This should be confirmed in future studies.