High clonal heterogeneity of Panton-Valentine leukocidin-positive meticillin-resistant Staphylococcus aureus strains from skin and soft-tissue infections in the Province of Bolzano, Northern Italy

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• 作者：Richard Aschbacher^a ; ^{richard.aschbacher@asbz.it} ; Bruno Pichon^b ; Greta Spoladore^c ; Elisabetta Pagani^a ; Patrizia Innocenti^a ; Ludwig Moroder^a ; Mark Ganner^b ; Robert Hill^b ; Rachel Pike^b ; Oswald Ganthaler^d ; Leonardo Pagani^c ; Clara Larcher^a ; Angela Kearns^b
• 关键词：Community-associated meticillin-resistant Staphylococcus aureus ; CA-MRSA ; SCCmec ; Arginine catabolic mobile element ; ACME ; Panton&ndash ; Valentine leukocidin ; PVL ; ST93
• 刊名：International Journal of Antimicrobial Agents
• 出版年：2012
• 期刊代码：126_09248579
• 类别：med
• 出版时间：June, 2012
• 卷：39
• 期：6
• 页码：522-525
• 文件大小：155 K

摘要

Panton-Valentine leukocidin (PVL)-positive community-associated meticillin-resistant Staphylococcus aureus (CA-MRSA) isolates are widespread in many countries, with varying distribution and epidemiology. The aim of this study was to characterise 10 PVL-positive MRSA isolates collected during February 2010 to January 2011 from skin and soft-tissue infections in the North Italian Province of Bolzano. Accessory gene regulator (agr) typing, staphylococcal cassette chromosome mec (SCCmec) typing, staphylococcal protein A (spa) gene typing, multilocus sequence typing, toxin gene profiling, polymerase chain reaction for type I arginine catabolic mobile element (ACME) and antimicrobial resistance typing were applied to the isolates. Eight different CA-MRSA clones were identified, including ST30-IVc, ST772-V, ST80-IVc, ST5-IVc, ST88-IVa, ST93-IVa, ST8-IVc and the type I ACME-positive ST8-IVa. The high heterogeneity of PVL-positive MRSA probably reflects the introduction of different clones by international travellers or immigrants.