Synthesis of chalcone derivatives on steroidal framework and their anticancer activities
- 作者：Hari Om Saxena ; Uzma Faridi ; J.K. Kumar ; Suaib Luqman ; M.P. Darokar ; Karuna Shanker ; Ch ; an S. Chanotiya ; M.M. Gupta ; Arvind S. Negi
- 关键词：Chalcone ; Estradiol ; Anticancer ; Erythrocyte ; Osmotic fragility
- 刊名：Steroids
- 出版年：2007
- 期刊代码：142_0039128x
- 类别：bio
- 出版时间：November 2007
- 卷：72
- 期：13
- 页码：892-900
- 文件大小：589 K
摘要
Chalcone derivatives on estradiol framework have been synthesized. Some of the derivatives showed potent anticancer activity against some human cancer cell lines. Compounds 9 and 19 showed potent activity against MCF-7, a hormone dependent breast cancer cell line. Chalcone 7 was further modified to the corresponding indanone derivative (19) using the Nazarov reaction, which showed better activity than the parent compound against the MCF-7 breast cancer cell line. Active anticancer derivatives were also evaluated for osmotic hemolysis using the erythrocyte as a model system. It was observed that chalcone derivatives showing cytotoxicity against cancer cell lines did not affect the fragility of erythrocytes and hence may be considered as non-toxic to normal cells.