Authors' Response
- 作者：Mó ; nica Povedano ; Jordi Gascó ; n ; Rafael Gá ; lvez ; Manuel Ruiz ; Javier Rejas
- 关键词：Cancer ; nausea ; vomiting ; opioid ; risperidone
- 刊名：Journal of Pain and Symptom Management
- 出版年：2007
- 期刊代码：166_08853924
- 类别：med
- 出版时间：July 2007
- 卷：34
- 期：1
- 页码：4-5
- 文件大小：39 K
摘要
Nausea and vomiting are distressing symptoms in advanced cancer patients. The causes of nausea and vomiting are multifactorial. Among the causes is opioid therapy, the mainstay of cancer pain management. When nausea or other opioid side effects occur, it may hamper pain management and undermine the quality of life of cancer patients. Risperidone exerts an antiemetic effect in animals, but there has been no clinical report on its antiemetic activity. We conducted a retrospective chart review to examine whether risperidone is useful for opioid-induced nausea and vomiting in advanced cancer patients (n = 20). Risperidone was given as doses of 1 mg once a day. Complete response was observed in 50%of patients (10/20) for nausea and 64%(7/11) for vomiting. Sedation (n = 2) was documented as an adverse effect. This observation suggests that risperidone can be an effective antiemetic drug in the treatment of refractory opioid-induced nausea and vomiting in advanced cancer patients.