MiR-26 controls LXR-dependent cholesterol efflux by targeting ABCA1 and ARL7

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• 作者：Dongsheng Sun^a ; Jun Zhang^b ; Jianhong Xie^a ; Wei Wei^b ; Mantao Chen^b ; Xiang Zhao^a ; ^{xiangzhao.xz@gmail.com}
• 关键词：LXR ; liver X receptors ; miRNA ; microRNA ; qPCR ; quantitative PCR ; ABCA1 ; ATP-binding cassette transporter A1 ; ARL7 ; ADP-ribosylation factor-like 7 ; RCT ; reverse cholesterol transport ; 3&prime ; UTRs ; 3&prime ; untranslated regions.
• 出版年：2012
• 期刊代码：70_00145793
• 类别：bio
• 出版时间：21 May, 2012
• 卷：586
• 期：10
• 页码：1472-1479
• 文件大小：968 K

摘要

Cellular cholesterol levels are tightly regulated and represent a balance of cholesterol uptake, endogenous synthesis and efflux. Although the classic transcriptional regulations of cholesterol metabolism by liver X receptors (LXRs) have been well studied, the potential effects of LXR-responsive microRNAs (miRNAs) still need to be unveiled. Here, we describe that miR-26, an LXR-suppressed miRNA, inhibits the expression of the ATP-binding cassette transporter A1 (ABCA1) and ADP-ribosylation factor-like 7 (ARL7), two LXR target genes which play critical roles in cholesterol efflux. These findings have not only figured out an alternative mechanism for LXR regulation, but also provided a potential therapeutic target for cholesterol metabolic disorders.