Liens physiopathologiques entre maladie de Kikuchi et lupus : à propos de trois nouvelles observations
- 作者：C. Leyral ; F. Camou ; C. Perlemoine ; O. Caubet ; J.L. Pellegrin and J.F. Viallard
- 关键词：Kikuchi-Fujimoto disease ; Histiocytic necrotizing lymphadenitis ; Systemic lupus erythematosus ; Hemophagocytic syndrome
- 刊名：La Revue de Medecine Interne
- 出版年：2005
- 期刊代码：237_02488663
- 类别：med
- 出版时间：2005
- 卷：26
- 期：8
- 页码：651-655
- 文件大小：394 K
摘要
Introduction. – Histiocytic necrotizing lymphadenitis or Kikuchi-Fujimoto's disease is a rare anatomoclinical entity whose etiology remains unknown. It is mainly reported in young adult female, presenting with cervical lymphadenopathies, fever and asthenia. The diagnosis is based on the histological examination of a lymph node biopsy. The disease course is usually uneventful, but sometimes Kikuchi-Fujimoto's disease can reveal or evolve into a cutaneous or a systemic lupus.
Exegesis. – We report three new cases of Kikuchi's disease: the first one mimicked a systemic lupus, the second one was associated with a lupus-like rash, and a the last one was a severe case with hemophagocytic syndrome and a primo-infection with Epstein-Barr virus revealing a systemic lupus erythematosus.
Conclusion. – Clinical and biological follow-up of patients presenting with Kikuchi's disease is necessary to look for an association with a lupus. We discuss the pathogenic links between Kikuchi's disease and lupus.