- 作者：Young-Hoon Joo ; Se-Hwan Hwang ; Jae-Hyun Seo ; Jun-Myung Kang ; entkjm@catholic.ac.kr
- 关键词：Lymph node tuberculosis ; Computer-assisted image processing ; Spiral computed tomography ; Treatment outcomes
- 刊名：Auris Nasus Larynx
- 出版年：2012
- 期刊代码：29_03858146
- 类别：med
- 出版时间：August, 2012
- 卷：39
- 期：4
- 页码：402-406
- 文件大小：484 K
Objective
The objective of this study was to investigate the feasibility of computerized segmentation of lymph nodes to evaluate the relationship of treatment outcomes in tuberculous cervical lymphadenitis (TCL).Methods
The study included 52 subjects with TCL that had CT before standard medical treatment. The relationship between the medication treatment response, volume and ratio of necrotic area of the largest lymph node in patients with TCL was evaluated. The treatment outcome was defined as the 鈥榬esponder鈥?(n = 35) and 鈥榥on-responder鈥?(n = 17) groups. Seventeen non-responder patients required surgery.
Results
The average lymph node volumes and ratio of necrotic area were 58.59 cm3 (range, 4.96-249.48 cm3) and 0.30 (range, 0-0.59), respectively. There was a significant difference in the lymph node volumes (34.91 卤 24.00 cm3 vs. 107.04 卤 69.12 cm3, p < 0.001) and ratio of necrotic area (0.26 卤 0.12 vs. 0.40 卤 0.14, p = 0.001) between responders and non-responders. The receiver-operating-characteristic (ROC) curve analysis was used for differentiating responders from non-responders; it showed that the area under the curve for the lymph node volumes and ratio of necrotic area was 0.845 and 0.759, respectively. The cut-off value for the lymph node volumes and ratio of necrotic area was 44.15 cm3 and 0.36 based on the ROC curve.
Conclusions
A large lymph node volume and high ratio of necrotic area on the 3D reconstruction of CT images were associated with the response to medical treatment for TB. These findings might be useful for assessing treatment outcomes.