Bone marrow necrosis complicating post-transplant lymphoproliferative disorder: Resolution with rituximab

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• 作者：Davide Rossi ; Antonio Ramponi ; Silvia Franceschetti ; Piero Stratta ; Gianluca Gaidano
• 关键词：Bone marrow necrosis ; Post-transplant lymphoproliferative disorder ; Renal transplantation ; Non-Hodgkin lymphoma ; Rituximab
• 刊名：Leukemia Research
• 出版年：2008
• 期刊代码：186_01452126
• 类别：med
• 出版时间：May 2008
• 卷：32
• 期：5
• 页码：829-834
• 文件大小：1123 K

摘要

Bone marrow necrosis is a rare cause of bone marrow failure. Malignancy is the most frequent cause of bone marrow necrosis. Among malignancies, non-Hodgkin lymphoma (NHL) accounts for 10%of cases of bone marrow necrosis. Virtually all reported cases of NHL-associated bone marrow necrosis have developed in immunocompetent hosts. We report on a case of bone marrow necrosis complicating post-transplant lymphoproliferative disorder (PTLD) and resolving after rituximab monotherapy. This case report provides the first evidence of (i) bone marrow necrosis as a complication of PTLD; (ii) rapid resolution of NHL-associated bone marrow necrosis after rituximab treatment.