Autophagy and cancer cell metabolism

详细信息	查看全文 | 推荐本文 |

• 作者：Fred Lozy^a ; ^b ; Vassiliki Karantza^a ; ^b ; ^c ; ^{karantva@umdnj.edu}
• 关键词：mTORC1 ; mammalian target of rapamycin complex 1 ; ULK1 ; Unc-51-like kinase complex ; Atg ; autophagy-related protein ; TSC ; tuberous sclerosis complex ; AMP ; adenosine monophosphate ; AMPK ; AMP kinase ; HIF ; hypoxia-inducible factor ; MAP1LC3B or LC3 ; microtubule
• 刊名：Seminars in Cell and Developmental Biology
• 出版年：2012
• 期刊代码：186_10849521
• 类别：bio
• 出版时间：June, 2012
• 卷：23
• 期：4
• 页码：395-401
• 文件大小：614 K

摘要

Autophagy is a catabolic process involving lysosomal turnover of proteins and organelles for maintenance of cellular homeostasis and mitigation of metabolic stress. Autophagy defects are linked to diseases, such as liver failure, neurodegeneration, inflammatory bowel disease, aging and cancer. The role of autophagy in tumorigenesis is complex and likely context-dependent. Human breast, ovarian and prostate cancers have allelic deletions of the essential autophagy regulator BECN1 and Becn1^{+/鈭?/sup> and other autophagy-deficient transgenic mice are tumor-prone, whereas tumors with constitutive Ras activation, including human pancreatic cancers, upregulate basal autophagy and are commonly addicted to this pathway for survival and growth; furthermore, autophagy suppression by Fip200 deletion compromises PyMT-induced mammary tumorigenesis. The double-edged sword function of autophagy in cancer has been attributed to both cell- and non-cell-autonomous mechanisms, as autophagy defects promote cancer progression in association with oxidative and ER stress, DNA damage accumulation, genomic instability and persistence of inflammation, while functional autophagy enables cancer cell survival under stress and likely contributes to treatment resistance. In this review, we will focus on the intimate link between autophagy and cancer cell metabolism, a topic of growing interest in recent years, which has been recognized as highly clinically relevant and has become the focus of intense investigation in translational cancer research. Many tumor-associated conditions, including intermittent oxygen and nutrient deprivation, oxidative stress, fast growth and cell death suppression, modulate, in parallel and in interconnected ways, both cellular metabolism and autophagy to enable cancer cells to rapidly adapt to environmental stressors, maintain uncontrolled proliferation and evade the toxic effects of radiation and/or chemotherapy. Elucidating the interplay between autophagy and tumor cell metabolism will provide unique opportunities to identify new therapeutic targets and develop synthetically lethal treatment strategies that preferentially target cancer cells, while sparing normal tissues.}