- 作者：Do ; Diana V. ; Shah ; Syed Mahmood ; Sung ; Jennifer U. ; Haller ; Julia A. ; Nguyen ; Quan Dong
- 刊名：American Journal of Ophthalmology
- 出版年：2005
- 期刊代码：7_00029394
- 类别：med
- 出版时间：April, 2005
- 卷：139
- 期：4
- 页码：620-623
- 文件大小：87.2 K
Purpose
To assess the correlation between persistent diabetic macular edema and hemoglobin A1c (HbA1C).Design
Retrospective study.
Methods
Records of type 2 diabetic patients who received eye care for persistent clinically significant macular edema (CSME) from January 2002 to January 2004 were reviewed. Subjects who met one of two criteria were identified: 1) persistent CSME, detected by contact lens biomicroscopy and fluorescein angiography, despite at least two focal laser photocoagulations (FLP) performed at least 3 months before the current diagnosis, or 2) a history of CSME with resolution of macular edema at the time of examination. Patients also needed to have had their HbA1C measured at the Johns Hopkins Hospitals within 3 months of meeting these criteria.
Results
The study identified 92 patients (152) eyes with persistent CSME and 32 patients (56 eyes) with resolved CSME. HbA1C values ranged from 5.3%to 15.6%(mean, 8.9%; median, 8.7%) and 5.3%to 9.7%(mean, 6.7%; median, 6.6%) among patients with persistent and resolved edema (P = .0005). Among the 32 patients with persistent unilateral CSME, mean HbA1C was 8.6%(median 8.5%), and among the 60 patients with bilateral CSME, mean HbA1C was 9.1%(median, 8.9%). Of patients with persistent CSME, 74%had HbA1C greater than 7.5%compared with 12.5%of the patients with resolved CSME (P = .0005).
Conclusions
Persons with type 2 diabetes and persistent CSME have higher HbA1C at time of their disease than patients with resolved CSME. Patients with bilateral disease have more elevated HbA1C than those with unilateral disease.