Flaxseed and its mammalian lignan precursor cause a lengthening or cessation of estrous cycling in rats

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• 作者：Orcheson ; Lindy J. ; Rickard ; Sharon E. ; Seidl ; Maja M. ; Thompson ; Lilian U.
• 关键词：Flaxseed ; Mammalian lignans ; Secoisolariciresinol diglycoside ; Estrous cycle ; Antiestrogens
• 刊名：Cancer Letters
• 出版年：1998
• 期刊代码：44_03043835
• 类别：med
• 出版时间：March 13, 1998
• 卷：125
• 期：1-2
• 页码：69-76
• 文件大小：659 K

摘要

Flaxseed and its mammalian lignan precursor secoisolariciresinol diglycoside (SDG) have been shown to be mammary cancer-protective in rats. Thus, the antiestrogenic effects of flaxseed and SDG were compared with tamoxifen, an antiestrogen, by monitoring rat estrous cycling. Four-week supplementation of a high-fat diet with flaxseed (2.5, 5, or 10%) or SDG (0.75, 1.5 or 3.0 mg/day) produced a dose-related cessation or lengthening (by 18–39%) of estrous cycles in up to 66%of rats. With tamoxifen (1 mg/kg body weight/day), 83%of the animals had irregular cycles or were in persistent diestrus. Flaxseed and SDG were antiestrogenic without gross tissue toxicity. size="-1" color="black"> Publisher: size="-1" color="black"> Elsevier Science size="-1" color="black"> Language of Publication: size="-1" color="black"> English size="-1" color="black"> Item Identifier: size="-1" color="black"> S0304-3835(97)00482-5 size="-1" color="black"> Publication Type: size="-1" color="black"> Article size="-1" color="black"> ISSN: size="-1" color="black"> 0304-3835 size="-1" color="black"> Cited by: size="-1" color="black">

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size="1"/>size="-1" color="black"> Footnotes:

1. This research on flaxseed and flaxseed meal is not an endorsement for the products by the US Food and Drug Administration.