IgG anti-toxoplasma antibodies among asymptomatic HIV-infected patients in Marrakesh-Morocco

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• 作者：Amal Addebbous^a ; ^{amal.add@gmail.com} ; Latifa Adarmouch^b ; Abdelali Tali^a ; Majda Laboudi^c ; Mohamed Amine^b ; Lahcen Aajly^d ; Mohamed Rhajaoui^c ; Laila Chabaa^a ; Laila Zougaghi^a
• 关键词：Toxoplasmosis ; HIV ; Seroprevalence ; Marrakesh ; Morocco
• 刊名：Acta Tropica
• 出版年：2012
• 期刊代码：2_0001706x
• 类别：imm
• 出版时间：July, 2012
• 卷：123
• 期：1
• 页码：49-52
• 文件大小：180 K

摘要

Detection and monitoring of anti-Toxoplasma gondii antibodies are of a great interest among human immunodeficiency virus (HIV)-infected patients, since cerebral toxoplasmosis is a life-threatening opportunistic infection within this vulnerable population. The IgG anti-T. gondii seroprevalence was assessed in 95 asymptomatic HIV-infected adults living in Marrakesh city and its surrounding areas. Our results showed a seroprevalence of 62.1%, which is high compared to most other countries. The mean of CD₄₊ T-cells count of involved patients was 381.9 cells/渭l. Given these results, HIV-infected patients in Marrakesh region could be at high risk to develop toxoplasmosis disease, especially when CD₄₊ T-cells count falls below 100 cells/渭l. Accordingly, there is a serious need of widening antiretroviral therapy and chemoprophylaxis against toxoplasmosis, when indicated, to ovoid toxoplasmosis reactivation among this population.