- 作者：Akifumi Kimura ; M.D.&lowast ; ; Satoshi Ono ; M.D.&dagger ; ; satoshi@ndmc.ac.jp ; Shuichi Hiraki ; M.D.&lowast ; ; Risa Takahata ; M.D.&lowast ; ; Hironori Tsujimoto ; M.D.&lowast ; ; Hiromi Miyazaki ; Ph.D.&dagger ; ; Manabu Kinoshita ; M.D.&Dagger ; ; Kazuo Hatsuse ; M.D.&lowast ; ; Daizoh Saitoh ; M.D.&dagger ; ; Kazuo Hase ; M.D.&lowast ; ; Junji Yamamoto ; M.D.&lowast ;
- 关键词：interleukin-15 ; sepsis ; pulmonary dysfunction ; renal dysfunction ; apoptosis
- 刊名：Journal of Surgical Research
- 出版年：2012
- 期刊代码：299_00224804
- 类别：med
- 出版时间：15 June, 2012
- 卷：175
- 期：2
- 页码：e83-e88
- 文件大小：574 K
Objective
To clarify the time course of changes in the serum interleukin-15 (IL-15) concentrations in septic patients undergoing emergency surgery for abdominal infection and to investigate whether the serum IL-15 levels correlate with the postoperative clinical course of septic patients.Methods
Twenty-four septic patients who had intra-abdominal infection and who underwent an emergency operation were enrolled in this study. The serum IL-15 levels were measured before surgery, and on postoperative d 1 (POD1), POD3, and POD5, and the relationship between the serum IL-15 levels and the postoperative clinical course estimated by the Systemic Inflammatory Response Syndrome (SIRS) criteria, Acute Physiology and Chronic Health Evaluation (APACHE-II) score, the parameters of organ function, and the 30-d mortality were evaluated.
Results
The time course of changes of the serum IL-15 levels were significantly different between survivors and non-survivors (P < 0.05, by repeated measures analysis of variance [ANOVA]). There was a statistically significant relationship between the serum IL-15 levels on POD1 or POD3 and the duration of SIRS (R = 0.50, P < 0.05, R = 0.65, P < 0.01, respectively). Furthermore, a significant positive correlation was observed between the serum IL-15 levels on POD1 and the creatinine levels on POD1 or POD3 (R = 0.48, P < 0.05, R = 0.50, P < 0.05, respectively), and a significant negative correlation between the serum IL-15 levels on POD1 or POD 3 and the PaO2/FiO2 on POD3 (R = -0.51, P < 0.05, R = -0.69, P < 0.01, respectively).
Conclusions
The measurement of postoperative serum level of IL-15 might be useful for predicting the severity of SIRS and organ dysfunction, especially renal and pulmonary dysfunction.