The synthesis of new, selected analogues of the pro-apoptotic and anticancer molecule HA 14-1

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• 作者：Danielle Gré ; e ; Samuel Vorin ; Vijay L. Manthati ; Fré ; dé ; ric Caijo ; Guillaume Viault ; Florence Manero ; Philippe Juin ; René ; Gré ; e
• 关键词：HA 14-1 ; Benzopyrane ; Anticancer ; Bcl-2
• 刊名：Tetrahedron Letters
• 出版年：2008
• 期刊代码：109_00404039
• 类别：ch
• 出版时间：12 May 2008
• 卷：49
• 期：20
• 页码：3276-3278
• 文件大小：108 K

摘要

A new and versatile strategy has been developed towards HA 14-1 analogues, selectively modified on position 4 and/or on the primary amine function. An important aspect was the appropriate selection of the phenol protective group in the 5-bromosalicylaldehyde, allowing the isolation of the key intermediate the 2H-benzopyrane-2-imine 2′.