Genome-wide studies of the transcriptional regulation by p53

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• 作者：Mangmang Li ; Yunlong He ; Xi Feng ; Jing Huang ; ^{huangj3@mail.nih.gov}
• 关键词：p53 ; Genome-wide ; Cancer ; Epigenetics ; Chromatin ; Histone
• 刊名：Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms
• 出版年：2012
• 期刊代码：P11_18749399
• 类别：bio
• 出版时间：July, 2012
• 卷：1819
• 期：7
• 页码：684-687
• 文件大小：293 K

摘要

The tumor suppressor p53 is arguably the most important transcription factor that safe-guards the genome. Although it is clear that the transcriptional activity of p53 is required for its tumor suppressive function, the underlying mechanisms are still largely unknown. In the past several years, genome-wide approaches have provided novel insights into the tumor suppressive functions of p53. This mini-review summarizes recent progress in studying these functions using genome-wide approaches, and offers some perspectives on this rapidly expanding field. This article is part of a Special Issue entitled: Chromatin in time and space.