• 作者：Antonio Ferná ; ndez Arias ^{afdzarias@hotmail.com}
• 关键词：Tuberculosis ; Interferó ; n ; Quantiferon ; QuantiferonTB ; Diagnó ; stico
• 刊名：Atenci贸n Primaria
• 出版年：2011
• 期刊代码：pca69_02126567
• 类别：med
• 出版时间：January 2011
• 卷：43
• 期：1
• 页码：18-25
• 文件大小：212 K

Objective

To compare the sensitivity, specificity and efficiency between Mantoux and Interferon-gamma techniques, using secondary sources.

Design

Study of the published literature with a high evidence-based sources of scientific information.

Data sources

A bibliographic search in the Cochrane database and Trip-database.

Study selection

We found three Clinical Practice Guidelines and nine articles, which included one Systematic Review, one Meta-analysis, one article on the sensitivity of the new techniques, three cost-efficiency studies, and three prospective studies on the role of interferon-gamma release in the diagnosis of TB.

Results

The new techniques have a higher specificity than Mantoux for the diagnosis of LTBI in contacts vaccinated in childhood with BCG. The most cost-effective diagnostic strategy for LTBI was Mantoux screening and confirmation with QFT-G.

Conclusion

Resources should be coordinated, limiting its use in studies of contacts in immunocompetent adults vaccinated with BCG, with Mantoux>5 mm or Tuberculin doubtful cases.