• 作者：Norberto Santana Rodr&#237 ; guez^a ; ^{norbesr@terra.es} ; Pedro Llontop Santisteban^a ; Ana Ló ; pez Garc&#237 ; a^b ; Bernardino Clavo^a ; Miguel Á ; ngel Ponce Gonzá ; lez^a ; Juan Carlos Rodr&#237 ; guez Bermejo^c ; José ; Manuel Garc&#237 ; a Castellano^d ; Ricardo Garc&#237 ; a Herrera^a ; Keila Zerecero^a ; José ; Antonio Ru&#237 ; z Caballero^e ; Yanira Brito Godoy^a ; André ; s Varela De Ugarte^f
• 关键词：Trasplante de pulmó ; n ; Rata ; Cuff ; Microcirugí ; a ; Muerte cerebral
• 刊名：Archivos de Bronconeumolog铆a
• 出版年：2011
• 期刊代码：pca65_03002896
• 类别：med
• 出版时间：October 2011
• 卷：47
• 期：10
• 页码：488-494
• 文件大小：467 K

Background

Microsurgical lung transplantation in rats has allowed us to obtain new knowledge about lung transplantation. However, some aspects in human transplantation technique still have not been included in this model, which could interfere with the clinical interpretation and extrapolation of results.

Methods

Twenty left lung transplantations were performed with a cuff technique and technical modifications, such as brain death induction, the control of ischemia time and retrograde perfusion in the donor and the controlled sequential reperfusion of the implanted lung in the recipient.

Results

Survival rate was 80%. The transplanted lungs showed proper perfusion and ventilation with good permeability of the anastomoses. Signs of ischemia-reperfusion injury were observed in all animals while mild acute rejection was seen in half of them.

Conclusions

The model shown proves valid and is very similar to the procedure carried out in humans, which would reduce the number of possible variables derived from the surgical technique when extrapolating the study results to clinical use.