S铆ndrome constitucional asociado a hepatotoxicidad por metformina
- 作者：Gema de la Poza Gó ; mez ; gpoza.hrc@salud.madrid.org ; Miguel Rivero Ferná ; ndez ; Manuel Vá ; zquez Romero ; Teresa Angueira Lapeñ ; a ; Gemma Arranz de la Mata ; Daniel Boixeda de Miquel
- 刊名：Gastroenterolog铆a y Hepatolog铆a
- 出版年：2008
- 期刊代码：pca167_02105705
- 类别：med
- 出版时间：December 2008
- 卷：31
- 期：10
- 页码：643-645
- 文件大小：75 K
摘要
Metformin is an oral antidiabetic agent frequently used to manage type II diabetes. This drug produces nonspecific gastrointestinal symptoms in 5-20%of patients and, more rarely, has also been associated with severe adverse effects such as lactic acidosis. Only a few isolated cases of hepatotoxicity due to this drug have been documented. We report the case of an 83-year-old man with constitutional syndrome and hepatic biochemical alterations, which were attributed to metformin after ruling out an oncologic etiology and observing complete clinical and biochemical resolution after withdrawal of the drug.