Inhibition of quorum sensing regulated biofilm formation in Serratia marcescens causing nosocomial infections
- 作者：Dhamodharan Bakkiyaraj ; Chandran Sivasankar ; Shunmugiah Karutha Pandian ; sk_pandian@rediffmail.com
- 关键词：Serratia marcescens ; Coral associated bacteria ; Quorum sensing ; Antibiofilm ; Quorum quenching ; Nosocomial infections
- 刊名：Bioorganic and Medicinal Chemistry Letters
- 出版年：2012
- 期刊代码：10_0960894x
- 类别：ch
- 出版时间：1 May, 2012
- 卷：22
- 期：9
- 页码：3089-3094
- 文件大小：1190 K
摘要
Serratia marcescens is an opportunistic pathogen causing severe urinary tract infections in hospitalized individuals. Infections of S. marcescens are of great concern because of its increasing resistance towards conventional antibiotics. Quorum sensing (QS)鈥攁 cell to cell communication鈥攕ystem of S. marcescens acts as a global regulator of almost all the virulence factors and majorly its biofilm formation. Since, the QS system of S. marcescens directly accords to its pathogenesis, targeting QS system will provide an improved strategy to combat drug resistant pathogens. In the present study, QS system of S. marcescens has been used as target and its inhibition has been studied upon exposure to bioactives from coral associated bacteria (CAB). This study also emphasises the potential of CAB in producing bioactive agents with anti-QS and antibiofilm properties. Two CAB isolates CAB 23 and 41 have shown to inhibit biofilm formation and the production of QS dependent virulence factors like prodigiosin, protease, lipase and swarming motility. The study, on the whole explicates the potential of QS system as a target to treat drug resistant bacterial infections.