Influence of AIN-93 diet on mortality and cardiac remodeling after myocardial infarction in rats

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• 作者：Lidiane P. Ardisson^a ; Marcos F. Minicucci^a ; Paula S. Azevedo^a ; Fernanda Chiuso-Minicucci^b ; Beatriz B. Matsubara^a ; Luiz S. Matsubara^a ; Priscila P. Santos^a ; Heloisa B. Assalin^a ; Rosangela Novo^a ; Ethel L. Novelli^c ; Lé ; a Silvia Sant'ana^d ; Sergio A.R. Paiva^a ; Leonardo A.M. Zornoff^a ; ^{lzornoff@fmb.unesp.br}
• 关键词：Heart failure ; Diet ; Rat ; Myocardial infarction ; Nutrition ; Remodeling
• 刊名：International Journal of Cardiology
• 出版年：2012
• 期刊代码：128_01675273
• 类别：med
• 出版时间：3 May, 2012
• 卷：156
• 期：3
• 页码：265-269
• 文件大小：246 K

摘要

Background

The AIN-93 diet was proposed by the American Institute of Nutrition with the objective of standardising studies in experimental nutrition. Our objective was to analyze the effects of AIN-93 diet after myocardial infarction in rats.

Methods

Post weaning, the animals were divided into two groups: control (C, n = 62), fed the standard diet of our laboratory (Labina); AIN-93 Group (n = 70), fed the AIN-93 diet. Achieving 250 g, the animals were subjected to myocardial infarction.

Results

Early mortality was increased in AIN-93 animals, associated with lower serum levels of calcium, magnesium, potassium, sodium, and phosphorus. On the other hand, after 90 days, AIN-93 showed smaller normalized left ventricular dimensions. The caloric and carbohydrate intake was smaller, but the fat intake was higher in AIN-93 rats. AIN-93 group also showed increased levels of 尾-hydroxyacylcoenzyme A dehydrogenase and citrate synthase. In addition, serum levels of insulin and cardiac levels of malondialdehyde, metalloproteinases-2 and -9, and TNF-伪 and IFN-纬 were decreased in the AIN-93 group.

Conclusion

AIN-93 diet increased early mortality, while attenuated the chronic remodeling process after experimental coronary occlusion. Therefore, this diet has biological effects and should be use with attention in this model.