Ianthellamide A, a selective kynurenine-3-hydroxylase inhibitor from the Australian marine sponge Ianthella quadrangulata

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• 作者：Yunjiang Feng^a ; ^{y.feng@griffith.edu.au} ; Bruce F. Bowden^b ; Vimal Kapoor^b
• 关键词：Ianthellamide A ; Kynurenine-3-hydroxylase ; Kynurenine pathway
• 刊名：Bioorganic and Medicinal Chemistry Letters
• 出版年：2012
• 期刊代码：10_0960894x
• 类别：ch
• 出版时间：15 May, 2012
• 卷：22
• 期：10
• 页码：3398-3401
• 文件大小：499 K

摘要

Ianthellamide A (1), a novel octopamine derivative, was isolated from the Australian marine sponge Ianthella quadrangulata. Compound 1 selectively inhibited the activity of kynurenine 3-hydroxylase with an IC₅₀ value of 1.5 渭M. It also significantly increased the level of endogenous kynurenic acid in rat brain and hence has the potential as a neuroprotective agent in the treatment of neurodegenerative disorders.