Anti-inflammatory cyclopeptides from the marine sponge Theonella swinhoei

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• 作者：Carmen Festa^a ; Simona De Marino^a ; Maria Valeria D&rsquo ; Auria^a ; Maria Chiara Monti^b ; Mariarosaria Bucci^c ; Valentina Vellecco^c ; Cé ; cile Debitus^d ; Angela Zampella^a ; ^{angela.zampella@unina.it} ; ^{azampell@unina.it}
• 关键词：Marine compounds ; Cyclopeptides ; Theonella swinhoei ; Anti-inflammatory activity
• 刊名：Tetrahedron
• 出版年：2012
• 期刊代码：107_00404020
• 类别：ch
• 出版时间：1 April, 2012
• 卷：68
• 期：13
• 页码：2851-2857
• 文件大小：466 K

摘要

DCCC chromatography followed by HPLC purification on the polar extract of marine sponge Theonella swinhoei resulted in the isolation of five new cyclopeptides, perthamides G-K. The new structures, featuring unprecedented amino acid units, were determined by interpretation of extensive spectroscopic and spectrometric data (MS, ¹H and ¹³C NMR, COSY, HSQC, HMBC, and ROESY). Pharmacological analysis demonstrated that these natural cyclopeptides are endowed with anti-inflammatory potential as assessed by their ability to reduce carrageenan-induced mouse paw oedema.